Luminalum may be available in the countries listed below.
Ingredient matches for Luminalum
Phenobarbital is reported as an ingredient of Luminalum in the following countries:
- Poland
International Drug Name Search
Luminalum may be available in the countries listed below.
Phenobarbital is reported as an ingredient of Luminalum in the following countries:
International Drug Name Search
Miansérine Arrow may be available in the countries listed below.
Mianserin hydrochloride (a derivative of Mianserin) is reported as an ingredient of Miansérine Arrow in the following countries:
International Drug Name Search
Erythrocine-ES may be available in the countries listed below.
Erythromycin ethylsuccinate (a derivative of Erythromycin) is reported as an ingredient of Erythrocine-ES in the following countries:
International Drug Name Search
Cliniderm may be available in the countries listed below.
Salicylic Acid is reported as an ingredient of Cliniderm in the following countries:
Triclosan is reported as an ingredient of Cliniderm in the following countries:
International Drug Name Search
Clemispray may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Clemispray in the following countries:
International Drug Name Search
Siccalactin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Benzylpenicillin benzathine (a derivative of Benzylpenicillin) is reported as an ingredient of Siccalactin in the following countries:
Dihydrostreptomycin sulfate (a derivative of Dihydrostreptomycin) is reported as an ingredient of Siccalactin in the following countries:
International Drug Name Search
Enalapril/Hydrochlorothiazide Arrow may be available in the countries listed below.
Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril/Hydrochlorothiazide Arrow in the following countries:
Hydrochlorothiazide is reported as an ingredient of Enalapril/Hydrochlorothiazide Arrow in the following countries:
International Drug Name Search
Pred Forte is a brand name of prednisolone ophthalmic, approved by the FDA in the following formulation(s):
Yes. The following products are equivalent to Pred Forte:
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Pred Forte. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
There are no current U.S. patents associated with Pred Forte.
Digestivo Giuliani may be available in the countries listed below.
Domperidone is reported as an ingredient of Digestivo Giuliani in the following countries:
International Drug Name Search
Minirin/Ddavp may be available in the countries listed below.
Desmopressin acetate (a derivative of Desmopressin) is reported as an ingredient of Minirin/Ddavp in the following countries:
International Drug Name Search
Naristar may be available in the countries listed below.
Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Naristar in the following countries:
Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Naristar in the following countries:
International Drug Name Search
Fenamisal is reported as an ingredient of Pheny-Pas-Tebamin in the following countries:
International Drug Name Search
Lyrinel may be available in the countries listed below.
UK matches:
Oxybutynin hydrochloride (a derivative of Oxybutynin) is reported as an ingredient of Lyrinel in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Cekodin may be available in the countries listed below.
Cefradine is reported as an ingredient of Cekodin in the following countries:
International Drug Name Search
Rec.INN
R01AC04,R06AX05
0000091-75-8
C17-H19-N3
265
Histamine, H₁-receptor antagonist
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| BANM | British Approved Name (Modified) |
| DCF | Dénomination Commune Française |
| DCIT | Denominazione Comune Italiana |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Ibuprofen Merck may be available in the countries listed below.
Ibuprofen is reported as an ingredient of Ibuprofen Merck in the following countries:
International Drug Name Search
Hepasel may be available in the countries listed below.
Biphenyl dimethyl dicarboxylate is reported as an ingredient of Hepasel in the following countries:
International Drug Name Search
A-vitel may be available in the countries listed below.
Retinol palmitate (a derivative of Retinol) is reported as an ingredient of A-vitel in the following countries:
International Drug Name Search
Mométasone may be available in the countries listed below.
Mométasone (DCF) is known as Mometasone in the US.
International Drug Name Search
Glossary
| DCF | Dénomination Commune Française |
Contrasal may be available in the countries listed below.
Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Contrasal in the following countries:
International Drug Name Search
Dorover may be available in the countries listed below.
Perindopril erbumine (a derivative of Perindopril) is reported as an ingredient of Dorover in the following countries:
International Drug Name Search
Voltamicin may be available in the countries listed below.
Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Voltamicin in the following countries:
Gentamicin sulfate (a derivative of Gentamicin) is reported as an ingredient of Voltamicin in the following countries:
International Drug Name Search
Adco-Alzam may be available in the countries listed below.
Alprazolam is reported as an ingredient of Adco-Alzam in the following countries:
International Drug Name Search
Ciprofibrate Biogaran may be available in the countries listed below.
Ciprofibrate is reported as an ingredient of Ciprofibrate Biogaran in the following countries:
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Volulyte may be available in the countries listed below.
Hetastarch is reported as an ingredient of Volulyte in the following countries:
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Eurythmic may be available in the countries listed below.
Amiodarone hydrochloride (a derivative of Amiodarone) is reported as an ingredient of Eurythmic in the following countries:
International Drug Name Search
Generic Name: clindamycin (Oral route, Injection route, Intravenous route)
klin-da-MYE-sin
Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin .
Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin .
Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin .
In the U.S.
In Canada
Available Dosage Forms:
Therapeutic Class: Antibiotic
Chemical Class: Lincosamide
Clindamycin is used to treat bacterial infections. It will not work for colds, flu, or other virus infections.
Clindamycin is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
This medicine has been tested in children and, in effective doses, has not been reported to cause different side effects or problems than it does in adults.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of clindamycin in the elderly with use in other age groups.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | B | Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. |
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
This section provides information on the proper use of a number of products that contain clindamycin. It may not be specific to Dalacin C Palmitate. Please read with care.
For patients taking the capsule form of clindamycin:
For patients taking the oral liquid form of clindamycin:
To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a ``strep'' infection, you should keep taking this medicine for at least 10 days. This is especially important in "strep" infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. For example, if you are to take 4 doses a day, doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Do not refrigerate the oral liquid form of clindamycin. If chilled, the liquid may thicken and be difficult to pour. Follow the directions on the label.
It is important that your doctor check your progress at regular visits.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
In some patients, clindamycin may cause diarrhea.
Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking clindamycin.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
(the above side effects may also occur up to several weeks after you stop taking this medicine)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.
Frubiase may be available in the countries listed below.
Calcium mixture of several salts (a derivative of Calcium) is reported as an ingredient of Frubiase in the following countries:
International Drug Name Search
Yellon may be available in the countries listed below.
Escin is reported as an ingredient of Yellon in the following countries:
International Drug Name Search
Generic Name: prenatal multivitamins (PRE nay tal VYE ta mins)
Brand Names: Advance Care Plus, Bright Beginnings, Cavan Folate, Cavan One, Cavan-Heme OB, Cenogen Ultra, CitraNatal Rx, Co Natal FA, Complete Natal DHA, Complete-RF, CompleteNate, Concept OB, Docosavit, Dualvit OB, Duet, Edge OB, Elite OB 400, Femecal OB, Folbecal, Folcaps Care One, Folivan-OB, Foltabs, Gesticare, Icar Prenatal, Icare Prenatal Rx, Inatal Advance, Infanate DHA, Kolnatal DHA, Lactocal-F, Marnatal-F, Maternity, Maxinate, Mission Prenatal, Multi-Nate 30, Multinatal Plus, Nata 29 Prenatal, Natachew, Natafort, Natelle, Neevo, Nestabs, Nexa Select with DHA, Novanatal, NovaStart, O-Cal Prenatal, OB Complete, OB Natal One, Ob-20, Obtrex DHA, OptiNate, Paire OB Plus DHA, PNV Select, PNV-Total, PR Natal 400, Pre-H-Cal, Precare, PreferaOB, Premesis Rx, PrenaCare, PrenaFirst, PrenaPlus, Prenatabs OBN, Prenatabs Rx, Prenatal 1 Plus 1, Prenatal Elite, Prenatal Multivitamins, Prenatal Plus, Prenatal S, Prenatal-U, Prenate Advanced Formula, Prenate DHA, Prenate Elite, Prenavite FC, PreNexa, PreQue 10, Previte Rx, PrimaCare, Pruet DHA, RE OB Plus DHA, Renate, RightStep, Rovin-NV, Se-Care, Se-Natal One, Se-Plete DHA, Se-Tan DHA, Select-OB, Seton ET, Strongstart, Stuart Prenatal with Beta Carotene, Tandem OB, Taron-BC, Tri Rx, TriAdvance, TriCare, Trimesis Rx, Trinate, Triveen-PRx RNF, UltimateCare Advance, Ultra-Natal, Vemavite PRX 2, VeNatal FA, Verotin-BY, Verotin-GR, Vinacal OR, Vinatal Forte, Vinate Advanced (New Formula), Vinate AZ, Vinate Care, Vinate Good Start, Vinate II (New Formula), Vinate III, Vinate One, Vitafol-OB, VitaNatal OB plus DHA, Vitaphil, Vitaphil Aide, Vitaphil Plus DHA, Vitaspire, Viva DHA, Vol-Nate, Vol-Plus, Vol-Tab Rx, Vynatal F.A., Zatean-CH, Zatean-PN
There are many brands and forms of prenatal vitamin available and not all brands are listed on this leaflet.
Prenatal vitamins are a combination of many different vitamins that are normally found in foods and other natural sources.
Prenatal vitamins are used to provide the additional vitamins needed during pregnancy. Minerals may also be contained in prenatal multivitamins.
Prenatal vitamins may also be used for purposes not listed in this medication guide.
There are many brands and forms of prenatal vitamin available and not all brands are listed on this leaflet.
Many multivitamin products also contain minerals such as calcium, iron, magnesium, potassium, and zinc. Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. Read the label of any multivitamin product you take to make sure you are aware of what it contains.
Overdose symptoms may include stomach pain, vomiting, diarrhea, constipation, loss of appetite, hair loss, peeling skin, tingly feeling in or around your mouth, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine, pale skin, and easy bruising or bleeding.
Before taking prenatal vitamins, tell your doctor about all of your medical conditions.
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Many multivitamin products also contain minerals such as calcium, iron, magnesium, potassium, and zinc. Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. Read the label of any multivitamin product you take to make sure you are aware of what it contains.
Swallow the regular tablet or capsule whole. Do not break, chew, crush, or open it.
The chewable tablet must be chewed or allowed to dissolve in your mouth before swallowing. You may also allow the chewable tablet to dissolve in drinking water, fruit juice, or infant formula (but not milk or other dairy products). Drink this mixture right away.
Use prenatal vitamins regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include stomach pain, vomiting, diarrhea, constipation, loss of appetite, hair loss, peeling skin, tingly feeling in or around your mouth, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine, pale skin, and easy bruising or bleeding.
Avoid the regular use of salt substitutes in your diet if your multivitamin contains potassium. If you are on a low-salt diet, ask your doctor before taking a vitamin or mineral supplement.
When taken as directed, prenatal vitamins are not expected to cause serious side effects. Less serious side effects may include:
upset stomach;
headache; or
unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Vitamin and mineral supplements can interact with certain medications, or affect how medications work in your body. Before taking a prenatal vitamin, tell your doctor if you also use:
diuretics (water pills);
heart or blood pressure medications;
tretinoin (Vesanoid);
isotretinoin (Accutane, Amnesteen, Clavaris, Sotret);
trimethoprim and sulfamethoxazole (Cotrim, Bactrim, Gantanol, Gantrisin, Septra, TMP/SMX); or
an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others.
This list is not complete and other drugs may interact with prenatal vitamins. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Aminophylline is reported as an ingredient of Aminophylline DF in the following countries:
International Drug Name Search
Amantadin AbZ may be available in the countries listed below.
Amantadine hydrochloride (a derivative of Amantadine) is reported as an ingredient of Amantadin AbZ in the following countries:
International Drug Name Search
Lacobile may be available in the countries listed below.
Ubidecarenone is reported as an ingredient of Lacobile in the following countries:
International Drug Name Search
Metenamina may be available in the countries listed below.
Metenamina (DCIT) is known as Methenamine in the US.
International Drug Name Search
Glossary
| DCIT | Denominazione Comune Italiana |
In the US, Tositumomab (tositumomab systemic) is a member of the following drug classes: CD20 monoclonal antibodies, radiologic conjugating agents.
US matches:
Rec.INN
L01XC,V09X,V10XA53
0208921-02-2
C6416-H9874-N1688-O1987-S44
143860
Antineoplastic agent
Immunomodulator
Monoclonal antibody
Immunoglobulin G2a anti-(human antigen CD 20) (mouse monoclonal clone B1R1 gamma 2a-chain), disulfide with mouse monoclonal clone B1R1 £ x-chain, dimer
International Drug Name Search
Glossary
| IS | Inofficial Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
In some countries, this medicine may only be approved for veterinary use.
Rec.INN
C04AX24
0000477-32-7
C21-H24-O7
388
Vasodilator
Butanoic acid, 2-methyl-, 10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, [9R-[9α(R*),10α]]-
International Drug Name Search
Glossary
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Perdophen pediatrie may be available in the countries listed below.
Ibuprofen is reported as an ingredient of Perdophen pediatrie in the following countries:
International Drug Name Search
Kofron may be available in the countries listed below.
Clarithromycin is reported as an ingredient of Kofron in the following countries:
International Drug Name Search
Losamel may be available in the countries listed below.
Omeprazole is reported as an ingredient of Losamel in the following countries:
International Drug Name Search
Anesketin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Ketamine is reported as an ingredient of Anesketin in the following countries:
Ketamine hydrochloride (a derivative of Ketamine) is reported as an ingredient of Anesketin in the following countries:
International Drug Name Search
Extinosad may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Extinosad in the following countries:
Spinosad is reported as an ingredient of Extinosad in the following countries:
International Drug Name Search
Generic Name: Fluocinolone Acetonide eent
Class: Corticosteroids
Chemical Name: (6α,11β,16α) - 6,9 - Difluoro - 11,21 - dihydroxy - 16,17 - [(1 - methylethylidene)bis(oxy)] - pregna - 1,4 - diene - 3,20 - dione
Molecular Formula: C24H30F2O6
Synthetic fluorinated corticosteroid.1
Management of chronic noninfectious uveitis affecting the posterior segment of the eye (designated an orphan drug by FDA for this use).1 2 4
Surgically implant intravitreally through a pars plana incision into posterior segment of eye.1
Maintain aseptic technique prior to and during the procedure to ensure sterility of the surgical field and implants.1 Do not resterilize implants by any method.1
Handle implants only by the suture tab to avoid damaging the implant; damage may increase rate of drug release.1
Avoid simultaneous implantation into both eyes in order to minimize risk of bilateral postoperative infections.1
Following depletion of fluocinolone acetonide from the implant, may remove the implant and replace with a new one to continue therapy.1
During implantation and explantation, avoid applying sheer forces on the implant that could disengage the silicone cup reservoir from the suture tab.1
Available as fluocinolone acetonide; dosage expressed in terms of the salt.1
Children ≥12 years of age: 0.59 mg (1 implant) in affected eye(s) approximately every 30 months.1 3
0.59 mg (1 implant) in affected eye(s) approximately every 30 months.1 3
Viral diseases of the cornea and conjunctiva (e.g., epithelial herpes simplex keratitis [dendritic keratitis], vaccinia, varicella).1
Mycobacterial infection of the eye.1
Fungal diseases of ocular structures.1
Known or suspected hypersensitivity to fluocinolone acetonide, other corticosteroids, or any ingredient in the formulation.1
Potential complications accompanying insertion of the implant may include cataract formation, choroidal or retinal detachment, temporary decrease in visual acuity, endophthalmitis, hypotony, increased intraocular pressure (IOP), exacerbation of intraocular inflammation, vitreous hemorrhage, vitreous loss, and wound dehiscence.1
Immediate and temporary decrease in visual acuity in the implanted eye will occur in most patients and may persist for 1–4 weeks after implantation.1
Risk of glaucoma with prolonged use of corticosteroids; monitor periodically for elevated IOP (e.g., every 3–6 months, more frequently in immediate postimplantation period).1 3 Use with caution in the presence of glaucoma.1
Approximately 60% of patients expected to require drug therapy to reduce IOP within 34 weeks after implantation.1 Within 2 years of implantation, 32% of patients expected to require filtering procedures for IOP control.1
Risk of prolongation or exacerbation of ocular viral infections (e.g., herpes simplex) with ophthalmic corticosteroids.1 Use with extreme caution in patients with history of herpes simplex.1
Risk of secondary ocular infection (bacterial, fungal, or viral) with prolonged use of corticosteroids.1 Consider possibility of fungal infection if persistent corneal ulceration occurs.1
In acute purulent conditions, corticosteroids may mask or enhance existing infections.1
Use of ophthalmic corticosteroids after cataract surgery may delay healing and increase bleb formation.1
Exercise caution in order to maintain sterility of and avoid damage to the implant.1 (See Administration under Dosage and Administration.)
Category C.1
Caution if used in nursing women.1 Not known whether ocular administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in milk.1
Systemically administered corticosteroids appear in milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other adverse effects.
Safety and efficacy not established in children <12 years of age.1
No substantial differences in safety and efficacy relative to younger adults.1
Cataracts, increased IOP, ocular pain, and surgical complications (e.g., cataract fragments in the eye, injury, mechanical complications, migration or expulsion of implant; wound complications or wound dehiscence) reported in 50–90% of patients.1
Reduced visual acuity, conjunctival hemorrhage or hyperemia, glaucoma, blurred vision, abnormal sensation in the eye, ocular irritation or inflammation, hypotony, pruritus, vitreous floaters or hemorrhage, ptosis, maculopathy, eyelid edema, increased tearing, and dry eye reported in 10–35% of patients.1
Headache was most frequent systemic effect.1
No formal drug interaction studies have been performed to date.3 However, because of limited systemic exposure, only intraocular interactions would be expected.3
Implant is designed to release fluocinolone acetonide locally to the posterior segment of the eye at a nominal initial rate of 0.6 mcg daily, decreasing over the first month to steady state of 0.3–0.4 mcg daily for approximately 30 months.1
Concentrations of the drug in aqueous and vitreous humor highly variable 1
Limited systemic exposure following intravitreal implantation; plasma concentrations are usually undetectable.1
15–25°C. Protect from freezing.1
Corticosteroids inhibit edema, fibrin deposition, capillary dilation, leukocyte migration, capillary and fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.1
Mechanism of ocular effects is unknown.1 Corticosteroids may induce phospholipase A2 inhibitory proteins; these proteins may inhibit release of arachidonic acid, thus controlling biosynthesis of potent mediators of inflammation (e.g., prostaglandins, leukotrienes).1
Importance of informing patients that fluocinolone acetonide treats ocular inflammation only and does not treat underlying disease.1
Importance of advising patients to return to clinician’s office for follow-up ophthalmologic examinations of both eyes at appropriate intervals following insertion of the implant.1
Importance of explaining risks of surgical complications, adverse ocular effects, and ocular infections.1
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses, especially glaucoma or existing bacterial, viral, or fungal infections of the eye.1
Importance of informing patients of other important precautionary information.1 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Ophthalmic | Implants | 0.59 mg | Retisert | Bausch & Lomb |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Fluocinonide 0.05% Cream (TEVA PHARMACEUTICALS USA): 30/$12.99 or 90/$36.97
Fluocinonide 0.05% Cream (TEVA PHARMACEUTICALS USA): 15/$11.99 or 45/$22.97
Fluocinonide 0.05% Cream (FOUGERA): 60/$14.99 or 180/$26.97
Fluocinonide 0.05% Gel (FOUGERA): 60/$37.99 or 180/$105.97
Fluocinonide 0.05% Gel (TARO): 30/$23.99 or 90/$67.97
Fluocinonide 0.05% Gel (FOUGERA): 15/$17.99 or 45/$49.97
Fluocinonide 0.05% Ointment (TARO): 60/$33.99 or 180/$90.96
Fluocinonide 0.05% Ointment (TARO): 15/$19.99 or 45/$54.97
Fluocinonide 0.05% Ointment (TEVA PHARMACEUTICALS USA): 30/$23.99 or 90/$67.97
Fluocinonide 0.05% Solution (TARO): 20/$23.99 or 40/$39.98
Fluocinonide 0.05% Solution (TEVA PHARMACEUTICALS USA): 60/$22.99 or 180/$64.99
Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 60/$17.99 or 180/$50.96
Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 30/$15.99 or 90/$41.97
Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 15/$16.99 or 45/$36.97
Vanos 0.1% Cream (MEDICIS): 30/$179.99 or 90/$499.97
Vanos 0.1% Cream (MEDICIS): 60/$280.99 or 180/$780.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions June 2006. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. Bausch & Lomb Incorporated. Retisert (fluocinolone acetonide intravitreal implant) 0.59 mg prescribing information. Rochester, NY; 2005 Apr.
2. Bausch & Lomb. Retisert (fluocinolone acetonide intravitreal implant) 0.59 mg formulary kit. Tampa, FL; 2005 May.
3. Bausch & Lomb, Rochester, NY: Personal communication.
4. Food and Drug Administration. Orphan designation pursuant to Section 526 of the Federal Food and Cosmetic Act as amended by the Orphan Drug Act (P.L. 97-414). Rockville, MD. From FDA website ().
Atiten may be available in the countries listed below.
Dihydrotachysterol is reported as an ingredient of Atiten in the following countries:
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Amlodipina Farmoz may be available in the countries listed below.
Amlodipine is reported as an ingredient of Amlodipina Farmoz in the following countries:
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Pravalip may be available in the countries listed below.
Pravastatin sodium salt (a derivative of Pravastatin) is reported as an ingredient of Pravalip in the following countries:
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Ultracain Suprarenin may be available in the countries listed below.
Articaine hydrochloride (a derivative of Articaine) is reported as an ingredient of Ultracain Suprarenin in the following countries:
Epinephrine hydrochloride (a derivative of Epinephrine) is reported as an ingredient of Ultracain Suprarenin in the following countries:
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Vioridon may be available in the countries listed below.
Baclofen is reported as an ingredient of Vioridon in the following countries:
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Aerovial may be available in the countries listed below.
Budesonide is reported as an ingredient of Aerovial in the following countries:
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Ivemend may be available in the countries listed below.
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Fosaprepitant is reported as an ingredient of Ivemend in the following countries:
Fosaprepitant dimeglumine (a derivative of Fosaprepitant) is reported as an ingredient of Ivemend in the following countries:
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Glossary
| SPC | Summary of Product Characteristics (UK) |
Loratadin-1A Pharma may be available in the countries listed below.
Loratadine is reported as an ingredient of Loratadin-1A Pharma in the following countries:
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Uronid may be available in the countries listed below.
Flavoxate hydrochloride (a derivative of Flavoxate) is reported as an ingredient of Uronid in the following countries:
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Esertia Paranova may be available in the countries listed below.
Escitalopram oxalate (a derivative of Escitalopram) is reported as an ingredient of Esertia Paranova in the following countries:
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Tebantin may be available in the countries listed below.
Gabapentin is reported as an ingredient of Tebantin in the following countries:
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Carbiquinone may be available in the countries listed below.
Ubidecarenone is reported as an ingredient of Carbiquinone in the following countries:
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Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take Diflunisal for a long time. Do not use Diflunisal right before or after bypass heart surgery.
Diflunisal may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.
Treating rheumatoid arthritis, osteoarthritis, or mild to moderate pain. It may also be used for other conditions as determined by your doctor.
Diflunisal is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Diflunisal. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Diflunisal. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Diflunisal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Diflunisal as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about the proper use of Diflunisal.
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Diflunisal side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; decreased urination; increased sweating; loss of consciousness; ringing in the ears; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow, fast, or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.
Store Diflunisal at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diflunisal out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Diflunisal. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.